CD8 cytotoxic T lymphocytes isolated from allogeneic healthy donors recognize HLA-class Ia/Ib-associated renal carcinoma antigens with ubiquitous or restricted tissue expression Short Title: RCC-reactive CTL in HLA-matched healthy donors
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چکیده
Andreas Dörrschuck, Andrea Schmidt, Elke Schnürer, Matthias Glückmann, Christian Albrecht, Catherine Wölfel, Volker Lennerz, Alexander Lifke, Carmela Di Natale, Elena Ranieri, Loreto Gesualdo, Christoph Huber, Michael Karas, Thomas Wölfel, and Wolfgang Herr From the Department of Medicine III, Hematology and Oncology, Johannes GutenbergUniversity of Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany; Institute of Pharmaceutical Chemistry, Johann Wolfgang Goethe-University of Frankfurt, Marie-Curie-Str. 9, 60439 Frankfurt/Main, Germany; Applied Biosystems, Frankfurter Str. 129B, 64293 Darmstadt, Germany; Department of Nephrology, University of Bari, Piazza Giulio Cesare 11, 70124 Bari, Italy
منابع مشابه
CD8+ cytotoxic T lymphocytes isolated from allogeneic healthy donors recognize HLA class Ia/Ib-associated renal carcinoma antigens with ubiquitous or restricted tissue expression.
Allogeneic hematopoietic stem cell transplantation can induce considerable tumor remissions in metastatic renal-cell carcinoma (RCC) patients. The precise effector mechanisms mediating these graft-versus-tumor reactions are unknown. We studied RCC-directed CD8(+) T-cell responses in blood lymphocytes of healthy individuals matched with established RCC cell lines for HLA-class I. In 21 of 22 all...
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Allogeneic cell therapy as a means to break immunotolerance to solid tumors is increasingly used for cancer treatment. To investigate cellular alloimmune responses in a human tumor model, primary cultures were established from renal cell carcinoma (RCC) tissues of 56 patients. In three patients with stable RCC line and human leukocyte antigen (HLA)-identical sibling donor available, allogeneic ...
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تاریخ انتشار 2004